Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
نویسندگان
چکیده
منابع مشابه
Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain.
Antidepressants are known to increase brain derived neurotrophic factor (BDNF) mRNA in the adult rat brain. The BDNF gene has four differentially regulated promoters that generate four transcript forms, each containing a unique non-coding 5' exon (exon I-IV) and a common 3' coding exon. Using in situ hybridization with exon-specific riboprobes, we have examined whether diverse classes of antide...
متن کاملBrain-derived neurotrophic factor and neuropsychiatric disorders.
Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the invo...
متن کاملThe mood stabilizer lamotrigine produces antidepressant behavioral effects in rats: role of brain-derived neurotrophic factor.
The anticonvulsant drug lamotrigine has been shown to produce strong antidepressant effects in the treatment of patients with bipolar disorder. However, to date there are few preclinical reports on its behavioral actions in animal models of depression or its underlying molecular mechanisms. The current study investigated the effects of lamotrigine in the forced swimming test and the learned hel...
متن کاملBrain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine.
The anticonvulsant drug lamotrigine has been shown to produce antidepressant effects in patients with bipolar disorder. To date, only a few preclinical studies have been conducted using lamotrigine treatment in the forced swim test (FST), an animal model of depression with low face validity. The underlying mechanisms by which lamotrigine works have not been well characterized either. This study...
متن کاملExplore the Features of Brain-Derived Neurotrophic Factor in Mood Disorders
OBJECTIVES Brain-derived neurotrophic factor (BDNF) plays important roles in neuronal survival and differentiation; however, the effects of BDNF on mood disorders remain unclear. We investigated BDNF from the perspective of various aspects of systems biology, including its molecular evolution, genomic studies, protein functions, and pathway analysis. METHODS We conducted analyses examining se...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2017
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2016.07.010